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Fetuin-A serum levels are not correlated to kidney function in long-lived subjects

Chiara Bellia1, Rossella Tomaiuolo, Antonietta Caruso

  • 1Sezione di Biochimica Clinica e Medicina Molecolare, Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università degli Studi di Palermo, Italy.

Clinical Biochemistry
|March 20, 2012
PubMed

Insights

Serum Fetuin A levels increase with age in elderly individuals. Lower levels of this protein were observed in those with specific AHSG gene variants, not linked to kidney function decline.

Area of Science:

  • Biochemistry
  • Gerontology
  • Nephrology

Background:

  • Serum Fetuin A inhibits ectopic calcification and is reduced in chronic kidney disease (CKD).
  • Aging is associated with arterial stiffening and kidney function decline.
  • Fetuin A is a potential link between CKD, arterial calcification, and aging.

Purpose of the Study:

  • To investigate the association between serum Fetuin A levels and aging.
  • To examine the relationship between serum Fetuin A and the AHSG T256S polymorphism.
  • To explore the correlation of serum Fetuin A with kidney function in senescence.

Main Methods:

  • Analysis of serum Fetuin A, Cystatin C, and AHSG T256S polymorphism in 256 elderly subjects (age 92 [81-100]).
  • Serum Fetuin A measured by ELISA.
  • AHSG T256S determined by PCR-RFLP.

Main Results:

  • Serum Fetuin A significantly correlates with age (r=0.20, P=0.0048).
  • AHSG TS and SS genotypes are associated with lower serum Fetuin A levels (P<0.027 and P<0.001, respectively).
  • No significant correlation was found between Fetuin A and Cystatin C (kidney function marker).

Conclusions:

  • Serum Fetuin A levels increase with age in elderly individuals.
  • Individuals with TS or SS AHSG polymorphism exhibit lower circulating Fetuin A.
  • The study did not find a correlation between serum Fetuin A and kidney function decline in aging individuals.
Abstract

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