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Updated: May 24, 2026

Transfecting and Nucleofecting Human Induced Pluripotent Stem Cells
Published on: October 5, 2011
[The genetic safety of induced pluripotent stem (iPS) cells]
1Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, China. cendy@mail.ustc.edu.cn
Abstract:
Since Takahashi and Yamanaka first generated induced pluripotent stem (iPS) cells from mouse fibroblasts successfully in 2006, iPS cells have rapidly become a new hotspot in the field of stem cells research because of their broad potential application prospects. Meanwhile, more and more attentions are paid to the genetic safety of iPS cells. This article summarizes recent findings on genetic safety of iPS cells and reviews the possible causes leading to genetic instability of iPS cells. Hopefully, this review is helpful to improve the induction of iPS cells and obtain genetically safe iPS cells.
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