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Current cell-based influenza vaccine production technology as pandemic contingency

Say Kong Ng1

  • 1Bioprocessing Technology Institute; Agency for Science, Technology and Research (A*STAR); Singapore. ng_say_kong@bti.a-star.edu.sg

Human Vaccines & Immunotherapeutics
|March 20, 2012
PubMed
Abstract

No abstract available in PubMed .

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Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...