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Related Experiment Video

Updated: May 24, 2026

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

Trps1 is necessary for normal temporomandibular joint development.

Ikumi Michikami¹, Toshiya Fukushi, Shiho Honma

¹Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.

Cell and Tissue Research

|March 20, 2012

Summary

The TRPS1 gene is crucial for normal temporomandibular joint (TMJ) development in mice. Its absence disrupts condylar process and joint disc formation, highlighting its essential role in jaw joint development.

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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

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Last Updated: May 24, 2026

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

Area of Science:

Developmental Biology
Genetics
Craniofacial Development

Background:

The TRPS1 gene is linked to trichorhinophalangeal syndrome (TRPS), affecting craniofacial development.
Trps1 expression in zebrafish jaw joints is known, but its role in mammalian temporomandibular joint (TMJ) development is unclear.

Purpose of the Study:

To investigate the expression pattern of Trps1 during mouse TMJ development.
To determine the necessity of Trps1 for proper TMJ formation using knockout models.

Main Methods:

Analysis of Trps1 expression in mouse TMJ at embryonic days E11.5 and E15.5.
Examination of TMJ development in Trps1 knockout mice at E14.5 and E18.5.
Assessment of chondrocyte differentiation and gene expression (Runx2) in mutant TMJs.

Main Results:

Trps1 is expressed in the developing maxillo-mandibular junction, condylar cartilage, and joint disc progenitors.
Trps1 knockout mice exhibit severely underdeveloped condylar processes and absent joint discs/cavities.
Mutant TMJs show delayed condyle initiation, altered chondrocyte maturation, and expanded Runx2 expression.

Conclusions:

Trps1 is indispensable for mammalian TMJ development.
It plays a vital role in differentiating joint disc and synoviocyte progenitor cells.
Trps1 coordinates chondrocyte differentiation within the developing condyle.