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Renal Sarcoidosis With Increased 1,25(OH)2D3 Production via CYP27B1-Expressing Epithelioid Granuloma: A Case Report
Shinya Harada1, Makoto Abe1, Yuko Ono2
1Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, JPN.
Abstract:
Sarcoidosis can cause acute kidney injury (AKI) through hypercalcemia and granulomatous interstitial nephritis. However, the detailed mechanisms linking intra-renal granuloma activity and AKI are not fully elucidated. A 69-year-old woman presented with AKI associated with elevated 1,25(OH)2D3 levels. A renal biopsy revealed tubulointerstitial nephritis with the presence of epithelioid granulomas and multinucleated giant cells. Immunohistochemistry showed that these cells expressed 25-hydroxyvitamin D-1 alpha hydroxylase (CYP27B1). Glucocorticoid therapy rapidly improved 1,25(OH)2D3 levels at initiation, but these levels fluctuated in relation to renal function during glucocorticoid tapering. Plasma 1,25(OH)2D3 may be produced by CYP27B1 expressed in renal granulomas and serves as an indicator for the treatment of renal sarcoidosis.
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