Hallucinations in Parkinson's disease: cross-sectional study
Marina Svetel1, Tatjana Smiljković, Tatjana Pekmezović
1Clinic of Neurology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 6, 11000 Belgrade, Serbia. marinasvetel@gmail.com
Acta Neurologica Belgica
|March 20, 2012
Summary
Hallucinations affect 13% of non-demented Parkinson's disease (PD) patients. Key risk factors include longer PD duration and higher neuropsychiatric inventory scores, independent of other variables.
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Parkinson's disease (PD) is a neurodegenerative disorder.
- Hallucinations are a common non-motor symptom in PD.
- Understanding risk factors for hallucinations is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of hallucinations in non-demented PD patients.
- To identify risk factors associated with hallucination development in PD.
Main Methods:
- Cross-sectional study of 180 non-demented Parkinson's disease patients.
- Data collected on patient demographics, disease characteristics, and medication.
- Statistical analysis including univariate and multivariate logistic regression.
Main Results:
- Prevalence of hallucinations was 13% (24/180 patients), with visual hallucinations being most common (90%).
- Univariate analysis linked hallucinations to age, PD duration, levodopa treatment details, dyskinesia, nightmares, UPDRS, HDRS, NPI scores, and H-Y stage.
- Multivariate analysis identified PD duration (p=0.024) and NPI total score (p=0.002) as independent risk factors.
Conclusions:
- Hallucinations are prevalent in non-demented PD patients.
- Longer disease duration and higher neuropsychiatric burden are significant independent predictors of hallucinations in Parkinson's disease.
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