A developmental and genetic classification for malformations of cortical development: update 2012
A James Barkovich1, Renzo Guerrini, Ruben I Kuzniecky
1Neuroradiology, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94913-0628, USA. james.barkovich@ucsf.edu
Brain : a Journal of Neurology
|March 20, 2012
Summary
Malformations of cerebral cortical development are common causes of neurodevelopmental delay and epilepsy. Recent advances in molecular biology, genetics, and imaging are refining our understanding and classification of these brain disorders.
Area of Science:
- Neuroscience
- Developmental Biology
- Genetics
Background:
- Malformations of cerebral cortical development are a significant cause of neurodevelopmental delay and epilepsy.
- Understanding these disorders is crucial for comprehending normal brain development and its abnormalities.
Observation:
- Recent advancements in molecular biology, genetics, and neuroimaging have dramatically increased knowledge of cerebral cortex development.
- This has led to the identification of numerous new types and classifications of cortical malformations.
Findings:
- The perception of malformations of cortical development is rapidly evolving due to new scientific insights.
- A modified classification is proposed, reflecting updated knowledge of cerebral cortical development.
Implications:
- This review highlights recent shifts in understanding these complex neurological disorders.
- The proposed classification aims to better categorize malformations of cortical development based on current scientific evidence.
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