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Updated: May 24, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Coercing bisphosphonates to kill cancer cells with nanoscale coordination polymers
Demin Liu1, Stephanie A Kramer, Rachel C Huxford-Phillips
1Department of Chemistry, CB#3290, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Abstract:
Nanoscale coordination polymers containing exceptionally high loadings of bisphosphonates were coated with single lipid bilayers to control the drug release kinetics and functionalized with a targeting ligand to endow cell-targeting capability, leading to much enhanced cytotoxicity against human lung and pancreatic cancer cells.
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