Related Experiment Video
Updated: May 23, 2026
06:31
Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
The relationship between adipose tissue and bone metabolism
Jeffrey M Gimble1, Mark E Nuttall
1Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA. gimblejm@pbrc.edu
Clinical Biochemistry
|March 21, 2012
Summary
The bone marrow microenvironment
Area of Science:
- Stem cell biology
- Endocrinology
- Aging research
Background:
- Bone marrow microenvironment supports mesenchymal stromal/stem cells (BMSCs) and hematopoietic stem cells (HSCs).
- BMSC fate is influenced by biological age and pathophysiology.
- Changes in bone marrow reflect the balance between BMSC adipogenesis and osteogenesis.
Purpose of the Study:
- To evaluate literature on the dynamic regulation of adipogenesis and osteogenesis.
- To provide a perspective on BMSC differentiation mechanisms.
Main Methods:
- Comprehensive literature search on PubMed.
- Keywords: adipogenesis, bone marrow, hematopoiesis, mesenchymal stromal/stem cell, osteogenesis.
Main Results:
- BMSC differentiation is regulated by hormonal factors and nuclear hormone receptor ligands.
- An inverse relationship exists between BMSC adipogenic and osteogenic processes.
- Endocrine feedback loops involve adipose tissue and the central nervous system.
Conclusions:
- Mechanisms regulating BMSC differentiation are crucial in aging, obesity, and osteoporosis.
- Understanding these mechanisms offers insights into bone and fat tissue interplay.
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