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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
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Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

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Gene therapy approaches to regenerating bone.

Nadav Kimelman Bleich1, Ilan Kallai, Jay R Lieberman

  • 1Skeletal Biotech Laboratory, The Hebrew University, Hadassah Faculty of Dental Medicine, Ein Kerem, Jerusalem, Israel. nadavk@ekmd.huji.ac.il

Advanced Drug Delivery Reviews
|March 21, 2012
PubMed
Summary

Gene therapy offers promising solutions for bone regeneration, addressing limitations of current treatments like recombinant human bone morphogenetic proteins (rhBMPs). This review explores advances, challenges, and future trends in gene therapy for skeletal repair.

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Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
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Published on: December 10, 2010

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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
07:53

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Area of Science:

  • Regenerative Medicine
  • Orthopedic Surgery
  • Gene Therapy

Background:

  • Skeletal disorders often require improved therapeutic strategies due to undertreatment.
  • Current bone formation and regeneration therapies, including recombinant human bone morphogenetic proteins (rhBMPs), face limitations and safety concerns.
  • Nonunion fractures and osteoporotic vertebral compression fractures highlight the need for advanced clinical solutions.

Purpose of the Study:

  • To review recent advancements in gene therapy for in vivo and ex vivo bone regeneration and formation.
  • To critically evaluate vectors, safety profiles, and bone formation rates associated with gene therapy approaches.
  • To discuss the translational relevance of animal models and identify future trends in bone regeneration gene therapy.

Main Methods:

  • Comprehensive literature review of gene therapy research focused on bone regeneration.
  • Analysis of studies examining different gene therapy vectors (in vivo and ex vivo).
  • Evaluation of safety data, bone formation efficacy, and the role of animal models in translational research.

Main Results:

  • Gene therapy presents a viable alternative to traditional bone regeneration methods, offering potential for enhanced efficacy and safety.
  • Various vectors and delivery methods (in vivo/ex vivo) are being explored, with ongoing research into optimizing bone formation rates.
  • Animal models are crucial for assessing the clinical translatability of gene therapy strategies, though challenges remain.

Conclusions:

  • Gene therapy holds significant promise for advancing bone formation and regeneration, addressing limitations of current treatments.
  • Further research is needed to overcome challenges related to vector safety, efficiency, and clinical translation.
  • Future trends point towards refined gene therapy techniques for improved skeletal repair and treatment of bone disorders.