Related Experiment Video
Updated: May 23, 2026

Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function
Published on: November 4, 2016
The microRNA regulatory network in normal- and HTLV-1-transformed T cells
Donna M D'Agostino1, Paola Zanovello, Toshiki Watanabe
1Department of Surgical Sciences, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Abstract:
Recent efforts to understand the molecular networks governing normal T cell development and driving the neoplastic transformation of T cells have brought to light the involvement of microRNAs (miRNAs), a class of noncoding RNAs of approximately 22 nucleotides that regulate gene expression at the posttranscriptional level. In the present review, we compare the expression profiles of miRNAs in normal T cell development to that of transformed T cells using as a model adult T cell leukemia/lymphoma, an aggressive malignancy of mature CD4+ T cells that is caused by infection with human T cell leukemia virus type 1.
Related Concept Videos
MicroRNAs
MicroRNAs
lncRNA - Long Non-coding RNAs

