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Related Concept Videos

General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...

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Related Experiment Video

Updated: May 23, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

[Pompe disease : anesthesiological special features].

J Lehberger1, R Roth, K Weingärtner

  • 1Klinik für Anästhesie, operative Intensivmedizin und Schmerztherapie, Sozialstiftung Bamberg - Klinikum am Bruderwald, Deutschland. judith.lehberger@sozialstiftung-bamberg.de

Der Anaesthesist
|March 21, 2012
PubMed
Summary

Pompe disease, a rare glycogen metabolism disorder, results from acid alpha-glucosidase deficiency. This case highlights respiratory insufficiency in adults with Pompe disease, crucial for anesthesia considerations.

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Last Updated: May 23, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
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Area of Science:

  • Biochemistry
  • Genetics
  • Metabolic Disorders

Background:

  • Pompe disease is a rare genetic disorder affecting glycogen metabolism.
  • It stems from a deficiency in the enzyme acid alpha-glucosidase.
  • Lysosomal glycogen accumulation leads to cellular damage.

Observation:

  • This case report details a 60-year-old male patient with Pompe disease.
  • The patient was scheduled for a prostate punch biopsy.
  • Adult-onset Pompe disease can present with varied clinical manifestations.

Findings:

  • Glycogen accumulation in lysosomes is characteristic of Pompe disease.
  • Skeletal and cardiac muscle involvement varies, impacting clinical presentation.
  • Respiratory insufficiency is a significant concern in adult patients.

Implications:

  • Anesthesiology procedures require careful consideration of respiratory status in Pompe disease patients.
  • Early diagnosis and management are vital for improving patient outcomes.
  • Understanding Pompe disease's varied presentation aids clinical decision-making.