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Nine kindreds of familial sticky platelet syndrome phenotype
Radoslava Šimonová1, Lenka Bartosová, Peter Chudy
1Department of Hematology and Transfusiology, National Center of Hemostasis and Thrombosis, Jessenius Faculty of Medicine, Comenius University, Martin University Hospital, Martin, Slovakia. radka.simon@gmail.com
Introduction:
Sticky platelet syndrome (SPS) is most likely a hereditary thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers--adenosine diphosphate and/or epinephrine. We present 9 kindreds with SPS familial occurrence.
Material And Methods:
Familial trait of SPS was looked up in the database of the National Center of Hemostasis and Thrombosis. Families with at least 3 SPS-positive members were studied, described, and presented.
Results:
In the group of 1093 symptomatic patients, SPS was confirmed in 240 cases. Familial occurrence with at least 3 SPS-positive relatives was found in 9 cases.
Conclusion:
The exact pathogenesis of SPS is not sufficiently explained. Our findings seem to support the idea that SPS might have an autosomal dominant hereditary fashion.
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