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Updated: May 23, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Microfluidic chemical analysis systems.

Eric Livak-Dahl1, Irene Sinn, Mark Burns

  • 1Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. elivak@umich.edu

Annual Review of Chemical and Biomolecular Engineering
|March 22, 2012
PubMed
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Microfluidic systems miniaturize lab functions for rapid chemical and biochemical analysis. These devices offer faster, more efficient methods with potential for widespread future use in various scientific fields.

Area of Science:

  • Microfluidics
  • Analytical Chemistry
  • Biochemistry

Background:

  • Microfluidics has rapidly advanced, integrating technologies from semiconductor manufacturing.
  • Miniaturized devices now perform complex chemical and biochemical analyses using nanoliter volumes and micrometer channels.

Purpose of the Study:

  • To review the diverse landscape of microfluidic analysis systems.
  • To highlight advancements from continuous flow to droplet-based and segmented flow systems.

Main Methods:

  • Fabrication of microfluidic devices using glass, silicon, and polymer substrates.
  • Utilizing electroosmotic pumping for liquid manipulation in microchannels.
  • Employing fluorescent detection for reaction product analysis.

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A Microfluidic Chip for ICPMS Sample Introduction
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Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
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Published on: November 27, 2013

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Last Updated: May 23, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
12:55

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Published on: November 27, 2013

Main Results:

  • Microfluidic systems enable significantly reduced analysis times compared to conventional techniques.
  • A variety of microfluidic architectures, including microarray and droplet-based systems, are described.
  • These systems handle complex chemical reactions and separations efficiently.

Conclusions:

  • Microfluidic analysis systems offer powerful miniaturized solutions for chemical and biochemical applications.
  • Despite current limitations, microfluidic technology holds significant potential for widespread adoption.
  • The field continues to evolve with diverse and innovative device designs.