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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Updated: May 23, 2026

Micro-scale Engineering for Cell Biology
04:42

Micro-scale Engineering for Cell Biology

Published on: October 1, 2007

Progress and prospects for stem cell engineering.

Randolph S Ashton1, Albert J Keung, Joseph Peltier

  • 1Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA.

Annual Review of Chemical and Biomolecular Engineering
|March 22, 2012
PubMed
Summary
This summary is machine-generated.

Stem cell research utilizes advanced technologies and computational biology to understand how microenvironmental cues control cell fate. This knowledge aims to enable predictable, scalable production of stem cell therapeutics for clinical use.

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Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Systems Biology

Background:

  • Stem cells possess self-renewal and differentiation capabilities, offering significant biomedical potential.
  • Understanding stem cell fate is crucial for therapeutic applications.
  • Novel technologies are emerging to investigate the complex regulation of stem cell behavior.

Purpose of the Study:

  • To explore how microenvironmental cues and cellular signaling influence stem cell fate.
  • To highlight the role of systems and computational biology in analyzing stem cell regulation.
  • To outline the development of technologies for predictable control of stem cell fate.

Main Methods:

  • Development of novel discovery technologies and cell culture systems.
  • High-throughput investigation of microenvironmental signals and intracellular pathways.
  • Application of theoretical modeling, systems biology, and computational biology methods.

Main Results:

  • Advanced technologies facilitate the study of microenvironmental signals and intracellular networks.
  • Systems and computational biology are essential for analyzing complex stem cell regulation data.
  • Empirical knowledge of stem cell regulation is continuously growing.

Conclusions:

  • Predictable control of stem cell fate is achievable through technological advancements.
  • Integration of experimental and computational approaches is key to understanding stem cell regulation.
  • Scalable, clinical-grade production of stem cell therapeutics is the ultimate goal.