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Published on: May 28, 2019
[Treatment of myocardial damage with creatine phosphate following neonatal asphyxia: a meta-analysis]
1Department of Neonatology, Children's Hospital Affiliated to Soochow University Suzhou, Jiangsu 215003, China.
Insights
Creatine phosphate (CP) treatment effectively reduces myocardial damage markers and hospitalization in neonates with asphyxia. Further high-quality research is needed to confirm these promising findings.
Area of Science:
- Neonatal Medicine
- Cardiology
- Biochemistry
Background:
- Neonatal asphyxia can lead to significant myocardial damage.
- Early intervention is crucial for improving outcomes in affected newborns.
- Creatine phosphate (CP) is being investigated for its cardioprotective potential.
Purpose of the Study:
- To systematically review and meta-analyze the efficacy of creatine phosphate (CP) in treating myocardial damage post-neonatal asphyxia.
Main Methods:
- A systematic literature review and meta-analysis of randomized and quasi-randomized trials.
- Inclusion of six trials with 400 patients (202 CP, 198 control).
- Data analysis performed using Review Manager 5.1.
Main Results:
- CP treatment for 7 days significantly decreased serum myocardial enzyme levels (CK, CK-MB, LDH, HBDH, cTnI).
- Higher total effective rates (RR: 1.29) and significantly effective rates (RR: 1.78) were observed in the CP group.
- CP treatment reduced hospitalization by an average of 4.07 days.
Conclusions:
- CP demonstrates potential as an effective and safe adjunct therapy for myocardial damage following neonatal asphyxia.
- CP therapy may reduce myocardial enzyme levels and shorten hospital stays.
- High-quality, large-scale trials are necessary to strengthen the evidence due to the current limitations in study quality.
Objective:
To evaluate the effects of creatine phosphate (CP) in the treatment of myocardial damage following neonatal asphyxia.
Methods:
Medical databases were searched for a systematic literature review and meta-analysis of randomized and quasi-randomized trials on the treatment of myocardial damage with CP following neonatal asphyxia. The data was analyzed using Review Manager 5.1.
Results:
Six trials involving 400 patients (CP treatment/control: 202/198) were included in the survey. The meta-analysis indicated that CP treatment for 7 days decreased serum myocardial enzyme levels (CK, CK-MB, LDH, HBDH and cTnI levels). Both the total effective rate (RR: 1.29; 95% CI: 1.12, 1.48) and the significantly effective rate (RR: 1.78; 95% CI: 1.32, 2.41) in the CP treatment group were significantly higher than in the control group. CP treatment reduced the hospitalization period by 4.07 days compared with the control group (95% CI: -5.25, -2.89).
Conclusions:
CP treatment appears to be more effective than routine treatment alone for myocardial damage following neonatal asphyxia. It appears to be safe and it can both decrease serum myocardial enzyme levels and shorten the period of hospitalization. However, as the evidence obtained in this study is not robust due to the poor quality of current studies, further studies of high-quality, large-scale trails are needed.
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