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Protecting mitochondrial bioenergetic function during resuscitation from cardiac arrest

Raúl J Gazmuri1, Jeejabai Radhakrishnan

  • 1Resuscitation Institute at Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA. raul.gazmuri@rosalindfranklin.edu

Critical Care Clinics
|March 22, 2012
PubMed
Summary

No abstract available in PubMed .

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Electron Transport Chain: Complex I and II01:46

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...

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