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Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
Eosinophilic gastroenteritis associated with multiple gastric cancer
Yasunori Otowa1, Masaaki Mitsutsuji, Takeshi Urade
1Department of Surgery, National Hospital Organization Kobe Medical Center, Kobe, Japan. otowa_y@kobemc.go.jp
European Journal of Gastroenterology & Hepatology
|March 22, 2012
Summary
This study reports a rare case of eosinophilic gastroenteritis (EG) associated with multiple gastric cancers in a 69-year-old man. The patient successfully responded to total gastrectomy and prednisolone treatment.
Area of Science:
- Gastroenterology
- Oncology
- Immunology
Background:
- Eosinophilic gastroenteritis (EG) is a rare inflammatory condition of the gastrointestinal tract.
- Symptoms of EG are non-specific and depend on the affected layer of the digestive tract.
- Association between EG and gastrointestinal malignancies is exceedingly rare.
Observation:
- A 69-year-old male presented with malaise, diarrhea, and dysgeusia.
- Endoscopy revealed edematous, reddish elevated lesions and three tumors in the gastric mucosa.
- Biopsies confirmed eosinophilic infiltration and tubular adenocarcinoma.
Findings:
- The patient was diagnosed with EG associated with multiple gastric cancers.
- Laboratory tests showed a slight elevation in serum IgE (480 IU/ml) but normal peripheral eosinophil counts.
- Allergy and parasitic tests were negative.
Implications:
- This case highlights a unique association between EG and gastric cancer.
- Surgical resection (total gastrectomy) and prednisolone treatment led to a good clinical response.
- Further research may be needed to understand the potential link between EG and gastric malignancies.
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