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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...

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NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
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NF-κB function in B lymphocytes.

Mary Kaileh1, Ranjan Sen

  • 1Gene Regulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Immunological Reviews
|March 23, 2012
PubMed
Summary
This summary is machine-generated.

Nuclear Factor kappa B (NF-κB) proteins are crucial for B-cell development, survival, and function. This review details their multifaceted roles in B lymphocytes, highlighting the need for deeper understanding of NF-κB gene expression.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • NF-κB proteins were initially identified for their role in regulating immunoglobulin κ light chain gene transcription in B lymphocytes.
  • Despite the enigmatic function of the κB site, NF-κB proteins are now recognized for critical roles in B-cell development, maintenance, and function.
  • This review provides an overview of B-cell biology and examines the specific functions of NF-κB family proteins.

Purpose of the Study:

  • To summarize the diverse functions of NF-κB proteins within B cells.
  • To examine the roles of NF-κB in B-cell development, mature B-cell survival, and overall B-cell function.
  • To explore potential mechanisms and implications of NF-κB-mediated gene expression in B lymphocytes.

Main Methods:

  • Literature review synthesizing existing research on NF-κB and B-cell biology.
  • Analysis of B-cell development stages and their regulation by NF-κB.
  • Examination of NF-κB's impact on mature B-cell survival and function.

Main Results:

  • NF-κB proteins play essential, multifaceted roles throughout B-cell lifecycles.
  • Specific functions span B-cell development, maintenance of mature cell populations, and execution of immune responses.
  • Evidence suggests complex regulatory mechanisms and broad implications for B-cell biology.

Conclusions:

  • NF-κB proteins are indispensable regulators of B-cell biology.
  • Further in-depth investigation into NF-κB-mediated gene expression is required.
  • Understanding these pathways is key to comprehending B-cell function and potential therapeutic targets.