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The relationship between clinical outcomes and medication adherence in difficult-to-control asthma

Anna C Murphy¹, Amandine Proeschal, Christopher E Brightling

¹Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK. anna.murphy@uhl-tr.nhs.uk

|March 23, 2012

Abstract

None:

Medication non-adherence and the clinical implications in difficult-to-control asthma were audited. Prescription issue data from 115 patients identified sub-optimal adherence (<80%) in 65% of patients on inhaled corticosteroids (ICS) or combined ICS/long-acting β2 agonist (LABA). In those using separate ICS and LABA, adherence to LABA (50%) was significantly better than to ICS (14.3%). Patients with sub-optimal ICS adherence had reduced FEV(1) and higher sputum eosinophil counts. Adherence ratio was an independent predictor of previous ventilation for acute severe asthma (p=0.008). The majority of patients with difficult-to-control asthma are non-adherent with their asthma medication. Non-adherence is correlated with poor clinical outcomes.

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