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Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands
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Alpha basic crystallin expression in canine mammary tumors.

Tolga Guvenc1, Mustafa Yavuz Gulbahar, Murat Yarim

  • 1Department of Pathology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Kurupelit, Samsun 55139, Turkey. tguvenc@omu.edu.tr

Journal of Veterinary Science
|March 23, 2012
PubMed
Summary

Alpha basic crystallin (αB-c) expression is significantly higher in malignant canine mammary tumors compared to benign ones. This finding suggests αB-c may serve as a diagnostic marker for canine mammary cancer.

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Area of Science:

  • Veterinary Pathology
  • Oncology
  • Biomarker Discovery

Background:

  • Canine mammary tumors (CMTs) represent a significant health concern in veterinary medicine.
  • Accurate diagnosis and prognosis are crucial for effective treatment strategies.
  • Identifying reliable prognostic and diagnostic factors for CMTs is an ongoing area of research.

Purpose of the Study:

  • To investigate the expression of alpha basic crystallin (αB-c) in canine mammary tumors.
  • To evaluate the potential of αB-c as a diagnostic and/or prognostic marker for canine mammary tumors.

Main Methods:

  • Immunohistochemical analysis of αB-c expression in 51 naturally-occurring canine mammary tumors (11 benign, 40 malignant) and 8 normal mammary glands.
  • Comparison of αB-c staining patterns and levels between normal, benign, and malignant tissues.

Main Results:

  • αB-c expression was detected in luminal epithelial cells of normal and benign tissues, with myoepithelial cells being negative.
  • In malignant tumors, αB-c was found in epithelial cells and also in neoplastic myoepithelial cells.
  • Significantly higher αB-c immunoreactivity was observed in malignant tumors compared to both benign lesions and normal mammary tissues (p < 0.001).

Conclusions:

  • αB-c expression levels are significantly different across normal, benign, and malignant canine mammary tissues.
  • Elevated αB-c expression is strongly associated with malignant canine mammary tumors.
  • αB-c shows potential as a valuable diagnostic biomarker for canine mammary cancer.