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Chemerin as a mediator between obesity and vascular inflammation in children

Kathrin Landgraf1, Daniela Friebe, Tina Ullrich

  • 1Pediatric Research Center, Department of Women's and Child Health, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany.

The Journal of Clinical Endocrinology and Metabolism
|March 23, 2012
PubMed

Insights

Chemerin levels are higher in obese children and linked to inflammation and early vascular changes. This suggests chemerin may connect excess fat to an increased risk of atherosclerosis in children.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Research
  • Metabolic Syndrome

Background:

  • Chemerin, a chemoattractant protein, is expressed in adipose tissue.
  • Obesity is associated with metabolic and vascular complications in children.

Purpose of the Study:

  • To investigate the association between chemerin and obesity in children.
  • To evaluate chemerin's link to early metabolic and vascular issues in pediatric obesity.

Main Methods:

  • Serum chemerin levels were measured in lean and obese children.
  • Associations with metabolic, inflammatory, and endothelial markers were assessed.
  • In vitro studies examined chemerin's effect on endothelial cells.

Main Results:

  • Obese children had significantly higher chemerin levels than lean children.
  • Chemerin correlated with obesity indicators, inflammation markers (hs-CRP, WBC), and endothelial activation markers (ICAM-1, E-selectin).
  • Chemerin was a strong predictor of ICAM-1 and E-selectin, and induced their expression in vitro.

Conclusions:

  • Chemerin is associated with obesity, inflammation, and endothelial activation in children.
  • Chemerin may serve as a link between increased fat mass and early atherogenic risk in obese children.
Abstract

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