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Related Experiment Videos

[Quantitative analysis of bone density in multiple myeloma].

B Bagni1, P N Scutellari, C Orzincolo

  • 1Servizio di Radiologia e Medicina Nucleare, Arcispedale S. Anna, Ferrara.

La Radiologia Medica
|October 1, 1990
PubMed
Summary

Osteopenia, a reduction in bone density, is significantly associated with advanced multiple myeloma (MM). Quantitative computed tomography (QCT) and dual-energy X-ray absorptiometry (DEXA) can assess bone loss in MM patients.

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Area of Science:

  • Oncology
  • Radiology
  • Bone Metabolism

Background:

  • Multiple myeloma (MM) is a malignant plasma cell disorder characterized by bone lesions.
  • Osteopenia and pathological fractures are common in MM, impacting diagnosis and prognosis.
  • Evaluating osteopenia's role is crucial for understanding MM progression.

Purpose of the Study:

  • To assess the significance of osteopenia in the diagnosis and prognosis of multiple myeloma.
  • To compare quantitative computed tomography (QCT) and dual-energy X-ray absorptiometry (DEXA) for bone densitometry in MM patients.

Main Methods:

  • Eighteen MM patients underwent QCT and DEXA for bone densitometry (lumbar spine, proximal femur).
  • Patients were classified using Durie's clinical criteria and Merlini's radiographic patterns.

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  • Bone densitometry results were correlated with clinical stage and bone marrow scintigraphy findings.

    • Main Results:

    • Patients with advanced MM (Stage III) and extensive bone marrow involvement showed significantly low bone density values via QCT and DEXA.
    • Both QCT and DEXA demonstrated substantial agreement in assessing bone density.
    • DEXA exhibited a higher rate of false positives compared to QCT.

    Conclusions:

    • Osteopenia is a key indicator in advanced multiple myeloma.
    • QCT is recommended for lumbar spine bone densitometry in MM diagnosis and monitoring.
    • A diagnostic protocol including radiography, bone marrow scintigraphy, and QCT is proposed for MM evaluation.