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Updated: May 23, 2026
08:31
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Functionalized mesoporous silica materials for controlled drug delivery.
Piaoping Yang1, Shili Gai, Jun Lin
1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
Chemical Society Reviews
|March 24, 2012
Summary
Mesoporous silica nanoparticles offer advanced, biocompatible drug delivery. Recent innovations include functionalized and stimuli-responsive systems, though in vivo applications face challenges.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery
Background:
- Mesoporous silica materials are increasingly recognized for their non-invasive and biocompatible properties.
- Significant advancements in structure control and functionalization (magnetism, luminescence) have been made for biotechnological and biomedical uses.
Purpose of the Study:
- To review recent progress in silica-based controlled drug delivery systems.
- To highlight functionalized and stimuli-responsive mesoporous silica carriers.
Main Methods:
- Review of recent research on mesoporous silica drug delivery systems.
- Categorization into pure silica, functionalized silica, and stimuli-responsive systems.
Main Results:
- Pure mesoporous silica enables sustained release.
- Functionalized systems offer integrated targeting and tracking.
- Stimuli-responsive systems react to environmental cues (pH, temperature, etc.).
Conclusions:
- Silica-based drug delivery shows promising developments.
- Challenges remain in multifunctional carrier design, mass production, and in vivo validation (biodistribution, toxicity, stability, efficacy).
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