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Cytomegalovirus Disease01:27

Cytomegalovirus Disease

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Related Experiment Video

Updated: May 23, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Disseminated Cryptococcus with ocular cryptococcoma in a human immunodeficiency virus-negative patient.

Zvi A Kresch1, Diego Espinosa-Heidmann, Tiffany Harper

  • 1Department of Ophthalmology, School of Medicine, West Virginia University, Morgantown, WV, USA. kreschz@wvuhealthcare.com

International Ophthalmology
|March 24, 2012
PubMed
Summary
This summary is machine-generated.

A man with autoimmune hemolytic anemia developed vision and hearing loss. Disseminated Cryptococcus infection, initially mistaken for sarcoidosis, was successfully treated with antifungal therapy.

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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

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Last Updated: May 23, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Immunology

Background:

  • Autoimmune hemolytic anemia (AIHA) is a condition where the immune system attacks red blood cells.
  • Human immunodeficiency virus (HIV)-negative individuals can also experience opportunistic infections.
  • Ocular and neurological manifestations can occur in disseminated fungal infections.

Observation:

  • A 63-year-old male with AIHA presented with decreased vision, photophobia, and hearing loss.
  • Initial diagnostic workup suggested sarcoidosis.
  • Further investigations revealed disseminated Cryptococcus infection with a left eye cryptococcoma.

Findings:

  • Disseminated Cryptococcus infection can mimic other granulomatous diseases like sarcoidosis.
  • Ocular cryptococcoma is a rare but serious manifestation of disseminated cryptococcosis.
  • Systemic antifungal therapy is effective in treating cryptococcal infections.

Implications:

  • Early and accurate diagnosis of disseminated fungal infections is crucial, even in HIV-negative patients.
  • Ophthalmologists and infectious disease specialists should consider fungal infections in patients with unexplained visual disturbances and systemic symptoms.
  • Prompt treatment with systemic antifungals can lead to favorable outcomes in disseminated cryptococcosis.