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Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Updated: Apr 10, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Hematologic Disorders: Blood Transfusion Products.

David Baltierra¹, Tiffany Harper¹, Matthew Page Jones¹

¹West Virginia University School of Medicine Robert C. Byrd Health Sciences Center-Eastern Division, 2500 Foundation Way, Martinsburg, WV 25401.

|June 17, 2015

Summary

This summary is machine-generated.

Liberal blood transfusion practices pose risks and are increasingly unsustainable. Restrictive criteria, patient monitoring, and alternative therapies like erythropoietin can improve outcomes and reduce costs.

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Area of Science:

Transfusion Medicine
Patient Safety

Background:

Historically, liberal blood transfusion criteria were common, lacking strong clinical evidence.
Blood transfusions carry significant risks, including infection, lung injury, and hemolytic reactions.

Purpose of the Study:

To evaluate the shift towards restrictive transfusion criteria.
To explore alternative strategies for managing anemia and reducing allogeneic blood use.

Main Methods:

Review of historical transfusion practices and associated risks.
Analysis of current restrictive transfusion strategies and patient monitoring.
Examination of alternative therapies like erythropoietin, iron, antifibrinolytics, and cell salvage.

Main Results:

Restrictive transfusion criteria decrease transfusion needs, associated risks, and healthcare costs.
Declining blood supply necessitates alternative strategies.
Preoperative autologous donation is often less favorable than previously thought.

Conclusions:

Implementing restrictive transfusion guidelines and patient monitoring is crucial for improving patient outcomes.
Preoperative erythropoietin/iron and intraoperative techniques effectively minimize the need for allogeneic blood transfusions.
Artificial blood products are not a viable alternative currently.