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Updated: May 23, 2026

14:53
A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
Published on: September 10, 2014
An ultrasensitive electrochemical DNA sensor based on the ssDNA-assisted cascade of hybridization reaction
Bin-Cheng Yin1, Yi-Meng Guan, Bang-Ce Ye
1Lab of Biosystem and Microanalysis, East China University of Science & Technology, Shanghai 200237, P.R. China.
Abstract:
We have developed a simple and ultrasensitive E-DNA sensor based on the ssDNA-assisted cascade of a hybridization reaction mechanism to form a long concatamers structure to improve its sensitivity, significantly. The proposed sensor was applied to sequence-specific DNA and ATP detection. Experimental results showed a quantitative measurement with the detection limit as low as 1 aM for specific DNA and 10 fM for ATP.
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