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The GP2 peptide: a HER2/neu-based breast cancer vaccine
Kevin S Clive1, Josh A Tyler, G Travis Clifton
1Department of Surgery, General Surgery Service, Brooke Army Medical Center, Ft. Sam Houston, Texas, USA.
Abstract:
Preclinical studies suggest that GP2, a HER2/neu-derived peptide, is immunogenic. Subsequent phase I clinical trials demonstrated that GP2-based vaccines are safe and effective in stimulating peptide-specific immunity. A GP2 peptide vaccine is currently being evaluated in a phase II efficacy trial enrolling breast cancer patients. This article reviews initial studies characterizing GP2, clinical trials investigating GP2-based vaccines, and novel immunotherapy strategies incorporating GP2 in combination with other peptides or with the monoclonal antibody trastuzumab.
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