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Synthesis of (±)-7-hydroxylycopodine.

Hong-Yu Lin1, Robert Causey, Gregory E Garcia

  • 1Department of Chemistry MS 015, Brandeis University, Waltham, Massachusetts 02454-9110, USA.

The Journal of Organic Chemistry
|March 27, 2012
PubMed
Summary

This study presents a seven-step synthesis of (±)-7-hydroxylycopodine, achieving a key tricyclic intermediate via a stereoselective Prins reaction. Novel oxidation reactions were also observed during attempts to create dihydroxylated analogs.

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