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Related Concept Videos

Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.

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Related Experiment Video

Updated: May 23, 2026

Ultralow Input Genome Sequencing Library Preparation from a Single Tardigrade Specimen
10:28

Ultralow Input Genome Sequencing Library Preparation from a Single Tardigrade Specimen

Published on: July 15, 2018

Toward the single-hour high-quality genome.

Patrik L Ståhl1, Joakim Lundeberg

  • 1Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77, Stockholm, Sweden. patrik.stahl@ki.se

Annual Review of Biochemistry
|March 27, 2012
PubMed
Summary

Rapid advancements in DNA sequencing technology allow for quick human genome resequencing, enabling new healthcare and research applications. However, data quality concerns arise with increasing speed and throughput.

Area of Science:

  • Genomics
  • Biotechnology
  • Bioinformatics

Background:

  • DNA sequencing technology has seen rapid performance improvements over the last seven years.
  • Human genome resequencing is now achievable within approximately one week using a single instrument.

Purpose of the Study:

  • To highlight the accelerating pace of DNA sequencing technology.
  • To discuss the expanding applications in healthcare, diagnostics, and research.
  • To address emerging concerns regarding data quality in rapidly growing databases.

Main Methods:

  • The abstract discusses the technological advancements in DNA sequencing platforms.
  • It references the increasing speed and throughput of genome sequencing.

Main Results:

More Related Videos

Ultra-long Read Sequencing for Whole Genomic DNA Analysis
10:34

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
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An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

Related Experiment Videos

Last Updated: May 23, 2026

Ultralow Input Genome Sequencing Library Preparation from a Single Tardigrade Specimen
10:28

Ultralow Input Genome Sequencing Library Preparation from a Single Tardigrade Specimen

Published on: July 15, 2018

Ultra-long Read Sequencing for Whole Genomic DNA Analysis
10:34

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
10:00

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

  • Human genome sequencing times have dramatically decreased.
  • The technology enables applications like immediate genetic characterization of contagious outbreaks.
  • Growing speed raises questions about the certainty and quality of deposited genomic data.

Conclusions:

  • The rapid evolution of DNA sequencing promises significant benefits for human health and research.
  • Future high-throughput, cost-effective technologies are anticipated.
  • Ensuring data quality and defining sequence certainty remain critical challenges.