Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Task-induced topological and geometrical changes in whole-brain dynamics predict cognitive individual differences.

bioRxiv : the preprint server for biology·2026
Same author

Comparing Dynamical Models Through Diffeomorphic Vector Field Alignment.

Neural computation·2026
Same author

On the control of recurrent neural networks using constant inputs.

IEEE transactions on automatic control·2026
Same author

Geometry of neural dynamics along the cortical attractor landscape reflects changes in attention.

Nature communications·2026
Same author

Multi-timescale Computation by Astrocytes.

bioRxiv : the preprint server for biology·2026
Same author

Two views of the brain are reconciled by a unifying principle of maximal information processing.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: May 23, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
08:49

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

Dynamical changes in neurological diseases and anesthesia.

Michelle M McCarthy1, ShiNung Ching, Miles A Whittington

  • 1Department of Mathematics and Statistics, Boston University, Boston, MA 02215, United States.

Current Opinion in Neurobiology
|March 27, 2012
PubMed
Summary

Changes in neuronal network function, often overlooked, stem from altered intrinsic and synaptic currents, not just connectivity. These non-structural changes are crucial in neurological disorders like Parkinson's disease and schizophrenia.

More Related Videos

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Related Experiment Videos

Last Updated: May 23, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
08:49

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Neuronal network dynamics are altered by changes in connectivity or intrinsic/synaptic currents.
  • Non-structural changes (currents) are often overlooked, especially when structural abnormalities are present.
  • These current-based changes may even drive observed structural alterations.

Purpose of the Study:

  • To highlight the significance of non-structural changes in neuronal network function.
  • To examine the role of altered currents in Parkinson's disease and schizophrenia.
  • To illustrate the impact of current changes using anesthesia as an acute model.

Main Methods:

  • Review of recent literature focusing on neuronal network dynamics.
  • Analysis of changes in intrinsic and synaptic currents.
  • Focus on the role of GABAergic function in microcircuits.

Main Results:

  • Non-structural changes in currents are critical contributors to abnormal network dynamics.
  • These changes are implicated in the pathophysiology of Parkinson's disease and schizophrenia.
  • Anesthesia demonstrates the potent effects of current alterations in the absence of structural changes.

Conclusions:

  • Altered intrinsic and synaptic currents are key drivers of aberrant neuronal network behavior.
  • Understanding these non-structural changes is vital for neurological disorders.
  • GABAergic function plays a significant role in these altered network dynamics.