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Left ventricular dysfunction assessed by cardiac time interval analysis among different geometric patterns in

Kunitsugu Takasaki1, Masaaki Miyata, Masakazu Imamura

  • 1Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|March 27, 2012
PubMed

Insights

The Tei index is a superior marker for detecting left ventricular (LV) dysfunction in hypertensive patients with hypertrophy. Concentric hypertrophy showed the most impaired LV function among all geometric patterns.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Left ventricular (LV) hypertrophy is a significant predictor of adverse outcomes in hypertensive individuals.
  • Abnormal LV geometric patterns, particularly concentric hypertrophy, are linked to increased mortality.
  • The relationship between LV geometry and cardiac dysfunction requires further elucidation.

Purpose of the Study:

  • To investigate the Tei index as a feasible parameter for assessing cardiac dysfunction across different LV geometric patterns in hypertensive patients.
  • To compare the Tei index's efficacy against conventional parameters in identifying LV dysfunction.

Main Methods:

  • Sixty untreated essential hypertensive patients were categorized into four groups: normal geometry, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy.
  • Ejection fraction, mitral E/A ratio, Tei index, ejection time, and isovolumic contraction/relaxation times were measured.
  • Correlations between LV mass index and hemodynamic/echocardiographic parameters were analyzed using regression analysis.

Main Results:

  • The Tei index showed a significant independent correlation with LV mass index.
  • Concentric hypertrophy was associated with a significantly increased Tei index compared to other geometric patterns.
  • The Tei index demonstrated significant correlations with LV mass index, ejection fraction, and mitral E/A ratio.

Conclusions:

  • The Tei index serves as a more effective marker for LV dysfunction in hypertensive hypertrophy than traditional parameters.
  • Patients with concentric hypertrophy exhibited the most severe impairment in LV function among all geometric patterns.
Abstract

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