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Segmentation of iodine brachytherapy implants in fluoroscopy
Eric Moult1, Gabor Fichtinger, W James Morris
1Queen's University, Kingston, Canada.
Summary
Accurate segmentation of iodine brachytherapy seeds is crucial for intraoperative dosimetry. A new region-based active contour model with template-based declustering achieves robust and precise seed localization.
Area of Science:
- Medical Imaging
- Radiation Oncology
- Computational Anatomy
Background:
- Intraoperative dosimetry in prostate brachytherapy requires 3D visualization of implanted seeds.
- Accurate seed segmentation is essential for evaluating implant quality during treatment.
Purpose of the Study:
- To develop and validate a robust method for segmenting iodine brachytherapy seeds.
- To enable accurate 3D seed localization for intraoperative dosimetry.
Main Methods:
- A region-based implicit active contour model was used for seed segmentation.
- A template-based declustering technique resolved overlapping seed groups.
Main Results:
- The algorithm achieved a 96.0% automatic detection rate on 55 clinical images.
- The false-positive rate was 2.2%, with a mean centroid error of 1.2 pixels.
- Validation was performed on 57 C-arm images from 10 patients.
Conclusions:
- The proposed segmentation workflow provides robust and accurate iodine seed segmentation.
- This method supports the development of intraoperative dosimetry for prostate brachytherapy.
