Idiopathic systemic AA-amyloidosis in a skunk (Mephitis mephitis)

Area of Science:

• Veterinary Pathology
• Comparative Pathology
• Mammalian Disease

Background:

• Systemic amyloidosis is a rare condition characterized by the extracellular deposition of misfolded proteins.
• Striped skunks (Mephitis mephitis) are not commonly reported to develop amyloidosis.
• Understanding amyloidosis in exotic species is crucial for accurate diagnosis and treatment.

Observation:

• A captive striped skunk presented with bilateral alopecia, renal, hepatic, and splenic enlargement upon necropsy.
• Gross pathological findings indicated significant organomegaly affecting multiple systems.
• Clinical signs were consistent with a systemic disease process.

Findings:

• Histopathological examination revealed amyloid deposition in various organs.
• Congo red staining confirmed the presence of amyloid.
• Immunohistochemistry identified the amyloid as AA-type, associated with chronic inflammation.

Implications:

• This case highlights the potential for systemic amyloidosis in striped skunks.
• The idiopathic nature of this case suggests a need for further research into underlying causes.
• Findings contribute to the knowledge base of amyloidosis in wildlife and captive exotic animals.