Related Experiment Video
Updated: May 23, 2026
05:27
Stromal Cell Isolation From Hematopoietic Organs
Published on: January 26, 2024
[Myelopoiesis and bone marrow function in elderly tumor patients]
1Fachbereich Geriatrie und Rehabilitation, Medizinische Klinik, St.-Bonifatius-Hospital Lingen, Akademisches Lehrkrankenhaus der Medizinischen Hochschule Hannover und der Westfälischen Wilhelms-Universität, Wilhelmstr. 15, 49808, Lingen, Deutschland. gerald.kolb@bonifatius-lingen.de
Zeitschrift Fur Gerontologie Und Geriatrie
|March 28, 2012
Summary
Elderly individuals experience reduced myelopoietic stem cells during hematopoietic stress, unlike younger people. This age-related decline compromises immune defenses, increasing risks for infections and sepsis.
Area of Science:
- Hematology
- Immunology
- Gerontology
Context:
- Human myelopoietic stem cell reserve shifts pools under immunological demand.
- Hematopoietic stress (sepsis, chemotherapy) differentially impacts stem cells in elderly vs. younger individuals.
- Age-related decline (≥70 years) impairs compensatory capacity and effector cell function.
Purpose:
- To investigate age-related changes in myelopoietic stem cell reserves and immune function.
- To analyze the impact of hematopoietic stress on stem cell populations in different age groups.
- To evaluate the role of comorbidities and cytokines in age-related immune compromise.
Summary:
- Hematopoietic stress reduces myelopoietic stem cells in the elderly, unlike in younger individuals, starting around age 70.
- Immune effector cell function (granulocytes, phagocytosis) and cytokine balance are compromised in aged organisms.
- Comorbidities, particularly chronic inflammation, significantly influence leukopenia and septicemia in the elderly.
Impact:
- Highlights the reduced capacity of aged organisms to recover from hematopoietic stress.
- Supports the prophylactic use of myelopoietic growth factors in elderly patients at risk of severe hematotoxicity.
- Underscores the need for prognostic tests to predict individual risk of hematotoxicity and septicemia in the elderly.
Related Concept Videos
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
01:19The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
01:21Hematopoiesis
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
01:20Overview of Hematopoiesis
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...