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Cardiac Action Potential01:30

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

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Related Experiment Video

Updated: May 23, 2026

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

Dialysis-dependent changes in ventricular repolarization.

Darren Green1, Velislav Batchvarov, Chandrakumara Wijesekara

  • 1Department of Renal Medicine, Salford Royal Hospital, Salford, United Kingdom. darrengreen@doctors.org.uk

Pacing and Clinical Electrophysiology : PACE
|March 29, 2012
PubMed
Summary
This summary is machine-generated.

Microvolt T-wave alternans (mTWA) during hemodialysis showed subtle changes but did not correlate with adverse cardiovascular outcomes. This electrocardiogram measure did not predict sudden death risk in dialysis patients.

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Optical Imaging of Isolated Murine Ventricular Myocytes
11:32

Optical Imaging of Isolated Murine Ventricular Myocytes

Published on: January 17, 2020

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Last Updated: May 23, 2026

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

Optical Imaging of Isolated Murine Ventricular Myocytes
11:32

Optical Imaging of Isolated Murine Ventricular Myocytes

Published on: January 17, 2020

Area of Science:

  • Cardiology
  • Nephrology
  • Electrophysiology

Background:

  • Hemodialysis is associated with an increased risk of sudden death.
  • Microvolt T-wave alternans (mTWA) is an ECG marker for abnormal ventricular repolarization and sudden death risk.
  • Dialysis-associated arrhythmias may be triggered by abnormal repolarization.

Purpose of the Study:

  • To investigate if mTWA measurements during hemodialysis indicate abnormal repolarization.
  • To assess mTWA as a potential indicator for dialysis-associated arrhythmias.

Main Methods:

  • 48-hour Holter ECG monitoring in maintenance hemodialysis patients.
  • Modified moving average mTWA analysis over 48 hours from dialysis initiation.
  • Assessment of predialysis biochemistry and echocardiography.

Main Results:

  • mTWA showed a statistically significant increase during hemodialysis, returning to baseline postdialysis.
  • No correlation was found between mTWA changes and serum biochemistry or echocardiographic parameters.
  • Neither peak mTWA nor increased frequency of mTWA spikes during dialysis predicted worse cardiovascular outcomes.

Conclusions:

  • Subtle changes in mTWA occur during hemodialysis.
  • These mTWA changes during dialysis are not associated with previously established markers of worse cardiovascular outcomes.
  • Abnormal mTWA during hemodialysis did not correlate with patient outcomes.