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Related Experiment Video

Updated: May 23, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Overactive bladder: correlating symptoms with low cystometric capacity.

Stacey L Grossman¹, Danny Lovatsis

¹From the Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Female Pelvic Medicine & Reconstructive Surgery

|March 29, 2012

Summary

This summary is machine-generated.

Overactive bladder (OAB) symptom questionnaires do not reliably predict low cystometric capacity (LCC). Further research is needed to improve OAB diagnosis accuracy using subjective and objective findings.

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Area of Science:

Urology
Gynecology

Background:

Overactive bladder (OAB) is a common condition characterized by urinary urgency, frequency, and incontinence.
Urodynamic testing is an objective method to assess bladder function, with low cystometric capacity (LCC) being a key urodynamic variable.

Purpose of the Study:

To investigate the correlation between patient-reported OAB symptoms and urodynamically determined LCC.
To evaluate the diagnostic accuracy of OAB symptom questionnaires in identifying LCC.

Main Methods:

A cross-sectional study involving 102 patients who completed an OAB symptom questionnaire and underwent multichannel urodynamic testing.
Diagnostic accuracy metrics (sensitivity, specificity, predictive values, Cohen's kappa) were calculated using a bladder capacity <350 mL as the reference for LCC.

Main Results:

57% of participants had urodynamically confirmed LCC (<350 mL).
49% of patients reported OAB symptoms, but the questionnaire showed only moderate diagnostic accuracy (sensitivity 57%, specificity 61%) and poor reliability (Cohen's kappa = 0.2).
Altering diagnostic criteria or including fluid intake data did not enhance accuracy.

Conclusions:

Patient-reported OAB symptoms do not reliably correlate with objectively measured LCC.
There is a need for further research to develop more accurate and minimally invasive diagnostic methods for OAB, integrating subjective and objective findings.