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Related Experiment Video

Updated: May 23, 2026

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Counting cells with a low-cost integrated microfluidics-waveguide sensor.

Daniel Garcia, Isaac Ghansah, John Leblanc

    Biomicrofluidics
    |March 29, 2012
    PubMed
    Summary
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    A novel, low-cost device enables rapid cell counting from blood using a waveguide sensor and metal nanoparticles. This technology offers affordable point-of-care diagnostics for resource-poor settings.

    Area of Science:

    • Biomedical Engineering
    • Optical Sensing
    • Point-of-Care Diagnostics

    Background:

    • Low-cost cell counting is crucial for diagnostics, especially in resource-limited areas.
    • Existing methods often require expensive detection instruments, hindering accessibility.

    Purpose of the Study:

    • To develop a novel, low-cost device for rapid cell counting from blood.
    • To enable point-of-care diagnostics in remote or resource-poor settings.

    Main Methods:

    • Fabrication of a planar waveguide in glass using ion exchange, integrated with a microfluidic cell-capturing structure.
    • Utilizing laser light transmission through the waveguide, attenuated by metal nanoparticles tagged to captured cells.
    • Calibration using bead-tagged lymphocytes from human blood.

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    Main Results:

    • Demonstrated a sensor capable of semi-quantitatively counting as few as 100 cells/µL of blood.
    • The device relies on the interaction of metal particles with the evanescent field of the waveguide.
    • Achieved enumeration of specifically captured cells.

    Conclusions:

    • The developed technology enables affordable and rapid cell counting.
    • This facilitates the creation of a point-of-care, hand-held device for medical screening.
    • Potential for significant impact in resource-poor settings and remote diagnostics.