Related Experiment Video
Updated: May 23, 2026

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
Published on: October 11, 2019
Interaction between debrisoquine and phenylephrine in man
W Allum1, J Aminu, T H Bloomfield
1Department of Pharmacology and Therapeutics, London Hospital Medical College, Turner Street, London.
Abstract:
1 The interaction between phenylephrine and debrisoquine was studied using normal and hypertensive human volunteers, measuring blood pressure, pulse rate and pupil diameter. Single doses of phenylephrine were given before, during and after a short course of debrisoquine treatment. 2 The circulatory effects of phenylephrine are potentiated by debrisoquine; in a few subjects this potentiation was marked and a potential hazard. 3 Limited deductions could be made about the effects of debrisoquine on baroceptor responses and adrenergic mechanisms.
Related Concept Videos
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
Depolarizing Blockers: Pharmocokinetics
Pharmacokinetics: Drug–Drug Interactions
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Pharmacokinetic–Pharmacodynamic Relationship: Problems