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A controlled trial of practolol in mild hypertension
D M Chaput de Saintonge1, C J Roberts, I D Strickland
1The Department of Clinical Pharmacology and Therapeutics, The London Hospital Medical College, Turner Street, London.
Abstract:
1 Fifteen patients with diastolic blood pressures between 90 and 120 mmHg were admitted to a trial comparing placebo with practolol at doses up to 500 mg 12 hourly. 2 The trial was a double blind cross over study. Treatments were allocated at random and each treatment block lasted 12 weeks. 3 Ten patients completed the trial, and none of those who withdrew experienced serious unwanted effects. 4 Practolol caused significant falls in standing systolic and diastolic pressures and the supine diastolic pressure.
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