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Updated: May 23, 2026
Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
[Study on the inhibitory effect of cepharanthine on herpes simplex type-1 virus (HSV-1) in vitro]
Xinjian Liu1, Yifei Wang, Meiying Zhang
1Jinan University, Guangzhou 510632.
Objective:
To assay the inhibitory effects of cepharanthine on HSV-1 in vitro.
Methods:
Vero cells were infected by HSV-1 and cultured with serial dilutions of cepharanthine. The inhibitory effects of cepharanthine were evaluated with cytopathogenic effects (CPE).
Results:
The CPE of cells infected by HSV-1 were inhibited significantly, resulting in higher cell survival rates.
Conclusion:
The results showed that cepharanthine had obvious HSV-1 inhibitory efficacy. Therefore, it may become a potential candidate in drug development and deserves further research on animal experiment and antiviral mechanisms.
