Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Nuclear Protein Sorting

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...

Nuclear Protein Sorting

Nuclear Protein Sorting

Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...

Directionality of Nuclear Transport

Directionality of Nuclear Transport

Ras-related nuclear protein or Ran is a small G protein that cycles between its GTP and GDP bound states. Ran specific regulators, a Ran GTPase Activating Protein or RanGAP present in the cytosol and a Ran guanine nucleotide exchange factor or RanGEF present inside the nucleus regulate GTP/GDP exchange. A high concentration of GTP inside the cells, in addition to this asymmetric distribution of Ran-specific regulators, leads to a higher RanGTP concentration inside the nucleus. This...

Nuclear Localization Signals and Import

Nuclear Localization Signals and Import

Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of 2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...

NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...

Nuclear Export

Nuclear Export

The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
NES are of three types- the canonical 10-residue long leucine-rich signal and other...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage.

Nature communications·2026

Same author

Morphogenetic Patterning During Regional and Cell Type Specification in the Embryonic Basal Ganglia.

bioRxiv : the preprint server for biology·2026

Same author

Adaptive evolution of gene regulatory networks in mammalian neocortex.

Nature·2026

Same author

SUPT16H-associated neurodevelopmental disorder and neurocristopathy: genetic and phenotypic spectrum.

Human molecular genetics·2026

Same author

Dose-dependent NFI regulation of progenitor lifespan and output underlying human neocortical malformation.

bioRxiv : the preprint server for biology·2026

Same author

Long-range axon branching: contributions to brain network plasticity and repair.

Nature reviews. Neuroscience·2026

Same journal

A Comprehensive Review of Melatonin as Multi-Pathway Neuroprotectant Against Methamphetamine-Induced Programmed Cell Death: Discovery of the Circadian-Ferroptosis Axis.

Neuro-Signals·2026

Same journal

The Impact of Vitamin D Deficiency on Cognitive and Neuromuscular Functions in Elderly Patients.

Neuro-Signals·2026

Same journal

Tracing the Evolution and Recombination Events of Neurotropic Arenaviridae Viruses: a Bioinformatics Approach.

Neuro-Signals·2025

Same journal

Peripheral Inflammation as a Biomarker of Disease Activity in Relapsing-Remitting MS.

Neuro-Signals·2025

Same journal

Aberrant Hippocampal Neuroregenerative Plasticity in Schizophrenia: Reactive Neuroblastosis as a Possible Pathocellular Mechanism of Hallucination.

Neuro-Signals·2024

Same journal

A Narrative Review - Therapy Options and Therapy Failure in Retinoblastoma.

Neuro-Signals·2022

See all related articles

Search research articles

Related Experiment Video

Updated: May 23, 2026

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

Nuclear factor I genes regulate neuronal migration.

Yee Hsieh Evelyn Heng¹, Guy Barry, Linda J Richards

¹School of Biomedical Sciences, Queensland Brain Institute, University of Queensland, Brisbane, Qld, Australia.

|March 30, 2012

Summary

This summary is machine-generated.

Nuclear Factor I transcription factors are crucial for brain development, regulating neuronal migration in the hippocampus and cerebellum. Understanding their role aids in addressing developmental brain disorders.

More Related Videos

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Published on: February 13, 2014

Related Experiment Videos

Last Updated: May 23, 2026

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Published on: February 13, 2014

Area of Science:

Neuroscience
Developmental Biology
Molecular Biology

Background:

Neuronal migration is essential for proper brain formation.
Deficits in neuronal migration are linked to neurological diseases.
Both intrinsic and extrinsic factors regulate neuronal migration.

Purpose of the Study:

To review the role of Nuclear Factor I (NFI) transcription factors in neuronal migration.
To explore NFI's contribution to hippocampus and cerebellum development.
To understand how NFI regulates the migration of specific neuronal populations.

Main Methods:

Review of existing literature on neuronal migration and NFI factors.
Analysis of studies using rodent models for brain development.
Focus on radial and tangential migration patterns in the cortex and cerebellum.

Main Results:

NFI proteins are key regulators of neuronal migration during brain development.
NFI factors influence the formation of the hippocampus and cerebellum.
Specific roles of NFI in radial migration of cortical neurons and cerebellar granule cells are highlighted.

Conclusions:

Nuclear Factor I transcription factors are vital for coordinating neuronal migration.
Dysregulation of NFI can lead to aberrant brain development and disease.
Further research into NFI functions can inform therapeutic strategies for neurological disorders.