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Updated: May 23, 2026

Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury
Published on: June 29, 2015
Inflammatory regulators of redirected neural migration in the injured brain
Nicole Bye1, Ann M Turnley, M Cristina Morganti-Kossmann
1National Trauma Research Institute, Alfred Hospital, Department of Surgery, Monash University, Melbourne, Vic, Australia. nicole.bye@monash.edu
Abstract:
Brain injury following stroke or trauma induces the migration of neuroblasts derived from subventricular zone neural precursor cells (NPCs) towards the damaged tissue, where they then have the potential to contribute to repair. Enhancing the recruitment of new cells thus presents an enticing prospect for the development of new therapeutic approaches to treat brain injury; to this end, an understanding of the factors regulating this process is required. During the neuroinflammatory response to ischemic and traumatic brain injuries, a plethora of pro- and anti-inflammatory cytokines, chemokines and growth factors are released in the damaged tissue, and recent work indicates that a variety of these are able to influence injury-induced migration. In this review, we will discuss the contribution of specific chemokines and growth factors towards stimulating NPC migration in the injured brain.
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