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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: May 23, 2026

Experimental Approaches to Tissue Engineering
16:41

Experimental Approaches to Tissue Engineering

Published on: August 30, 2007

Tissue bioengineering and artificial organs.

Sara Llames1, Eva García, Jesús Otero Hernández

  • 1Tissue Engineering Unit, Community Centre for Blood and Tissues of Asturias, Biomedical Network Research Centre on Rare Diseases, Oviedo, Spain.

Advances in Experimental Medicine and Biology
|March 30, 2012
PubMed
Summary

Tissue engineering (TE) aims to create organs in the lab by expanding cells, seeding them in scaffolds, and grafting. A major challenge for TE is developing vascular networks for larger engineered tissues.

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Last Updated: May 23, 2026

Experimental Approaches to Tissue Engineering
16:41

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Published on: August 30, 2007

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08:34

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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Biomaterials Science

Background:

  • Organ and tissue scarcity for transplantation necessitates laboratory-based production.
  • Immunosuppressive drugs are required to prevent rejection of transplanted organs.
  • Tissue engineering (TE) offers a potential solution for regenerating organs and tissues.

Purpose of the Study:

  • To review current challenges and potential solutions in laboratory-based organ and tissue production.
  • To discuss the status of TE techniques across different organ systems.
  • To highlight the critical need for vascularization in engineered tissues.

Main Methods:

  • Ex vivo cell expansion.
  • Seeding cells in 3D scaffolds mimicking physiological conditions.
  • Grafting of engineered tissue prototypes.

Main Results:

  • TE can regenerate organs from fragments or produce multiple organs from a single donor.
  • The absence of vascularization technology is the primary limitation for large TE constructs.
  • Current thin TE tissues rely on diffusion for nutrient supply.

Conclusions:

  • Developing vascular trees is essential for the success of large-scale tissue engineering.
  • Overcoming vascularization challenges is key to advancing laboratory-based organ development.
  • TE techniques show promise for regenerating various organ systems, but vascular integration remains a hurdle.