Related Experiment Video
Updated: May 23, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
Differential patterns of connectivity in progressive mild cognitive impairment
Ricardo Bajo1, Nazareth P Castellanos, Pablo Cuesta
1Laboratory of Cognitive and Computational Neuroscience, Centre of Biomedical Technology (CTB), Complutense University of Madrid (UCM) and Technological University of Madrid (UPM), Madrid, Spain. ricardo.bajo@ctb.upm.es
Abstract:
It is now widely accepted that Alzheimer's disease is characterized by a functional disconnection between brain regions. The disease appears to begin up to decades prior to clinical diagnosis. Therefore, in the present study, we combined magnetoencephalography, a memory task, and functional connectivity analysis in mild cognitive impairment subjects in order to identify functional connectivity patterns that could characterize subjects who would eventually go on to develop the disease. We monitored 19 subjects and finally 5 of them developed Alzheimer's disease. These progressive patients showed a differential profile of functional connectivity values compared with those patients who remained stable over time. Specifically there were higher synchronization values over the parieto-occipital region in α and β frequency bands. The involvement of this brain region in amyloid-β accumulation and its possible association with hyper-synchronization are also discussed.
More Related Videos
09:38Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
09:01A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
Published on: May 7, 2014
Related Concept Videos
Dementia l: Introduction
Alzheimer Disease ll: Pathophysiology
Alzheimer Disease l: Introduction
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Cognitive Development During Adulthood