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Updated: May 23, 2026
09:21
Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
Published on: February 23, 2024
Low molecular weight iron dextran increases fibroblast growth factor-23 concentration, together with parathyroid
Tomasz Hryszko1, Alicja Rydzewska-Rosolowska, Szymon Brzosko
1Department of Nephrology and Transplantation, Medical University of Bialystok, Bialystok, Poland. tomhry@mp.pl
Summary
Intravenous low molecular weight iron dextran (LMID) increases fibroblast growth factor-23 (FGF-23) and decreases parathyroid hormone (PTH) in hemodialysis patients. This suggests a link between iron supplementation and parathyroid gland suppression.
Area of Science:
- Nephrology
- Endocrinology
- Bone Metabolism
Background:
- Elevated fibroblast growth factor-23 (FGF-23) and parathyroid hormone (PTH) are common in hemodialysis (HD) patients.
- Iron polymaltose increases FGF-23, but the effect of intravenous low molecular weight iron dextran (LMID) on FGF-23, PTH, and bone metabolism in HD patients is unknown.
Purpose of the Study:
- To investigate the effect of a single LMID infusion on FGF-23, PTH, and bone metabolism markers in HD patients.
Main Methods:
- Prospective study of 12 HD patients receiving a single LMID infusion.
- Measurements of calcium, phosphate, FGF-23, PTH, CTX, and PINP at baseline, week 1, and week 3 post-infusion.
Main Results:
- LMID significantly increased FGF-23 levels at week 1 (P = 0.001) and decreased PTH levels (P = 0.018).
- FGF-23 and PTH levels tended to return to baseline by week 3.
- No significant changes were observed in calcium, phosphate, CTX, or PINP.
Conclusions:
- LMID administration leads to increased FGF-23 and decreased PTH concentrations in HD patients.
- This finding suggests a potential pathophysiological link between intravenous iron supplementation and parathyroid gland suppression in this population.
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