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Related Concept Videos

Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Eukaryotic Transcription Activators02:42

Eukaryotic Transcription Activators

Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...

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Related Experiment Video

Updated: May 23, 2026

Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences
11:25

Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences

Published on: February 11, 2019

The transcription factor encyclopedia.

Dimas Yusuf1, Stefanie L Butland, Magdalena I Swanson

  • 1Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada.

Genome Biology
|March 31, 2012
PubMed
Summary
This summary is machine-generated.

The Transcription Factor Encyclopedia (TFe) is a new open-access resource providing expert-vetted mini reviews on human, mouse, and rat transcription factors (TFs). It offers a PDF generator and web API for easy access to TF information.

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

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Related Experiment Videos

Last Updated: May 23, 2026

Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences
11:25

Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences

Published on: February 11, 2019

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
07:05

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA

Published on: September 8, 2021

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Transcription factors (TFs) are crucial proteins regulating gene expression.
  • A need exists for a centralized, accessible resource for TF information.
  • Existing resources may lack comprehensive, expert-curated reviews.

Purpose of the Study:

  • To establish the Transcription Factor Encyclopedia (TFe) as a collaborative, open-access compendium of TF mini reviews.
  • To provide scientists with succinct, expert-written summaries of TFs.
  • To facilitate rapid education and understanding of TFs.

Main Methods:

  • Development of a web-based platform (TFe) for hosting mini review articles.
  • Consortium of over 100 researchers contributing content.
  • Inclusion of features such as a PDF generator and a web API.

Main Results:

  • Publication of over 130 mini review articles covering human, mouse, and rat TFs.
  • Establishment of an open-access platform promoting collaboration.
  • Implementation of tools for data retrieval and information dissemination.

Conclusions:

  • TFe serves as a valuable, centralized resource for transcription factor knowledge.
  • The platform's open-access and collaborative nature fosters scientific advancement.
  • TFe enhances the ability of researchers to quickly learn about relevant TFs.