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Updated: May 23, 2026

High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies
07:10

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Contribution of tumoral and host solute carriers to clinical drug response

Jason A Sprowl1, Torben S Mikkelsen, Hugh Giovinazzo

  • 1Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|March 31, 2012
PubMed

Insights

Solute carrier transporters influence anticancer drug uptake and resistance. Understanding their role is crucial for improving cancer treatment efficacy and managing side effects.

Area of Science:

  • Molecular Biology
  • Pharmacology
  • Oncology

Background:

  • Solute carrier (SLC) transporters facilitate cellular uptake of compounds.
  • SLCs are expressed in cancer cells, impacting drug absorption and resistance.
  • Altered SLC expression affects drug efficacy, interactions, and side effects.

Purpose of the Study:

  • Review the role of SLCs in anticancer drug disposition.
  • Highlight SLCs' contribution to drug uptake in tumors.
  • Discuss SLCs as potential therapeutic targets in oncology.

Main Methods:

  • Literature review of solute carrier transporters in cancer.
  • Analysis of SLC expression in cancer cell lines and tumors.
  • Evaluation of SLCs in anticancer drug uptake and resistance mechanisms.

Main Results:

  • SLCs directly impact anticancer drug uptake in tumor cells.
  • SLCs play a significant role in regulating the disposition of anticancer drugs.
  • Emerging strategies aim to target SLCs for enhanced cancer therapy.

Conclusions:

  • Solute carriers are critical determinants of anticancer drug efficacy.
  • Targeting SLCs offers a promising avenue for overcoming drug resistance.
  • Further research into SLCs can optimize cancer treatment strategies.

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