Is there a role for inherited TRβ mutation in human carcinogenesis? [corrected]

Letícia Schwerz Weinert1, Lucieli Ceolin, Mírian Romitti

  • 1Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, RS, Brazil.

Insights

Resistance to thyroid hormone (RTH) is a rare genetic disorder caused by thyroid hormone receptor beta (TRβ) gene mutations. This case highlights a patient with RTH and papillary thyroid cancer, exploring the link between TRβ mutations and tumorigenesis.

Area of Science:

  • Endocrinology
  • Genetics
  • Oncology

Background:

  • Resistance to thyroid hormone (RTH) is a rare inherited disorder due to thyroid hormone receptor (TR) β gene mutations.
  • It presents with variable clinical features, commonly goiter, and reduced end-organ sensitivity to thyroid hormones.

Observation:

  • A 29-year-old patient with RTH, caused by a specific TRβ gene mutation (A317T in exon 9), presented with multicentric papillary thyroid cancer.
  • This case is uncommon and prompts further investigation into the association between RTH and thyroid malignancy.

Findings:

  • Thyroid-stimulating hormone (TSH) levels are elevated in RTH and correlate with an increased risk of thyroid cancer.
  • TRβ mutations are increasingly associated with human cancers, though their precise role in carcinogenesis remains unclear.

Implications:

  • Understanding the role of TRβ mutants in tumorigenesis is crucial for defining cancer risk in RTH patients.
  • This research highlights the need for careful patient follow-up and management strategies for individuals with RTH and associated thyroid abnormalities.

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