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Updated: May 23, 2026

Light Sheet Microscopy of Fast Cardiac Dynamics in Zebrafish Embryos

Light Sheet Microscopy of Fast Cardiac Dynamics in Zebrafish Embryos

Published on: August 13, 2021

Optical mapping in the developing zebrafish heart.

M Khaled Sabeh¹, Hussein Kekhia, Calum A Macrae

¹Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Pediatric Cardiology

|March 31, 2012

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Zebrafish models enable early heart development research. These models are crucial for understanding cardiac electrophysiology and discovering new drugs by screening genetic and chemical modifiers.

Area of Science:

Developmental biology
Cardiovascular research
Pharmacology

Background:

Studying early heart development and electrical activity is difficult due to inaccessibility.
The zebrafish (Danio rerio) has emerged as a key model organism for developmental studies.
Zebrafish offer genetic and chemical screening capabilities.

Purpose of the Study:

To explore the developmental basis of cardiac electrical activity.
To leverage zebrafish for experimental investigation of cardiogenesis.
To utilize zebrafish for genetic and chemical screening of electrophysiologic phenotypes and drug discovery.

Main Methods:

Utilizing zebrafish as a model organism for studying heart formation.
Employing genetic screening to identify modifiers of cardiac electrophysiology.

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Functional Cardiac Imaging in Zebrafish Embryos Using Standard Microscopy and Video Analysis: Applications in Environmental and Biomedical Research

Functional Cardiac Imaging in Zebrafish Embryos Using Standard Microscopy and Video Analysis: Applications in Environmental and Biomedical Research

Published on: October 10, 2025

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis

Published on: May 26, 2021

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Last Updated: May 23, 2026

Light Sheet Microscopy of Fast Cardiac Dynamics in Zebrafish Embryos

Light Sheet Microscopy of Fast Cardiac Dynamics in Zebrafish Embryos

Published on: August 13, 2021

Functional Cardiac Imaging in Zebrafish Embryos Using Standard Microscopy and Video Analysis: Applications in Environmental and Biomedical Research

Functional Cardiac Imaging in Zebrafish Embryos Using Standard Microscopy and Video Analysis: Applications in Environmental and Biomedical Research

Published on: October 10, 2025

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis

Published on: May 26, 2021

Conducting chemical screening for novel drug discovery related to heart function.

Main Results:

Zebrafish facilitate experimental access to early heart formation stages.
The model system supports robust genetic and chemical screening approaches.
These methods have been successfully applied to identify electrophysiologic phenotype modifiers and potential drugs.

Conclusions:

Zebrafish are a powerful model for investigating the developmental basis of cardiac electrical activity.
The genetic and chemical screening platforms in zebrafish are valuable for cardiovascular research.
This approach aids in the discovery of novel therapeutic strategies for cardiac conditions.